The chapel, dedicated to Saint John the Baptist, patron of Florence, presents a complex iconography of the Zanchini family and the sacrifice of Christ. The decorative sequence begins from the ceiling, with a commemoration of the creation and then unravels on the walls with the Baptist's life. At the end of the last restoration work by students of the “Palazzo Spinelli” Institute in 2006, a closer stylistic bond was established with the works by Santi di Tito's disciple, Benedetto Veli (late 16th century).